Doxorubicin cardiotoxicity and Camellia sinensis cardioprotection determined by speckle-tracking echocardiography

Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including risk cardiotoxicity. Flavonoids are plant metabolites antioxidant properties can be extracted from Camellia sinensis (CS). The aim this study to evaluate possible cardioprotective effect CS against injuries induced by Dox rats. A total 32 animals were distributed into four groups: (1) control - intraperitoneal injection (I.P.) 0.5 mL saline weekly 1.0 water gavage daily; (2) I.P. 200 mg/kg (3) 5.0 (4) Dox+CS -5.0 daily. Clinical examinations, blood profiles, electrocardiograms, echocardiograms, histological analyses hearts performed over 25 days. group showed changes body weight erythrogram, leukogram, electrocardiography, echocardiography readings. However, dox+CS had significantly less change weight, improved cardiac function, more preserved tissue. This demonstrated that prevents dox-induced cardiotoxicity, despite enhancing cytotoxic on cells.